Journal Title：Structure

Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding, and/or design, will also be considered. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single-molecule analysis of biological mechanisms are welcome.

In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure-activity relationships and will not consider studies that solely report structural information unless the structure or analysis is of exceptional and broad interest. Studies reporting only homology models, de novo models, or molecular dynamics simulations are also discouraged unless the models are informed by or validated by novel experimental data; rationalization of a large body of existing experimental evidence and making testable predictions based on a model or simulation is often not considered sufficient.

Structure 旨在发表结构生物学领域特别感兴趣的论文。该杂志力求成为结构生物学家以及对大分子结构和功能感兴趣的生物学家和生物化学家的必备读物。结构强烈鼓励提交对生物学功能和机制提出结构和分子见解的手稿。也将考虑解决结构生物学中基本问题的其他报告，例如基于结构的蛋白质进化、折叠和/或设计检查。我们将考虑以高分辨率或低分辨率应用任何实验或计算方法来进行结构研究，只要该方法适用于正在解决的生物学、功能和机械问题。同样，欢迎描述生物机制的单分子分析的报告。

一般而言，编辑鼓励提交通过结构-活性关系分析丰富的实验结构研究，并且不会考虑仅报告结构信息的研究，除非结构或分析具有特殊和广泛的兴趣。仅报告同源模型、从头模型或分子动力学模拟的研究也不鼓励，除非模型得到新的实验数据的启发或验证；对大量现有实验证据进行合理化并基于模型或模拟做出可测试的预测通常被认为是不够的。